Action for Primates

Long-tailed macaques, photo by Sarah Kite
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Experiments Using Non-human Primates, Published in 2022

In our news or take action pages, we report on the types of research to which non-human primates are being subjected. Bear in mind that these reports comprise only a few of the dozens of similar experiments published each week. See elsewhere for examples from previous years.

Although we emphasise welfare issues with respect to how the research impacted on the individuals, please bear in mind that the non-human primates used were all essentially wild animals, even if bred in captivity. Because of this, the suffering and stress of being in captivity was inherent in every case.

You can find out more information on all grants made by the National Institutes of Health, the largest funding entity in the US, and all their agencies by using the NIH RePORTER. You can search by grant number, investigator, recipient institution and more (see instructions).

2022-08-01: Cleveland, David C.; Jagdale, Abhijit; Carlo, Waldemar F.; Iwase, Hayato; Crawford, Jack; Walcott, Gregory P.; Dabal, Robert J.; Sorabella, Robert A.; Rhodes, Leslie; Timpa, Joey; Litovsky, Silvio; O'Meara, Carlisle; Padilla, Luz A.; Foote, Jeremy; Mauchley, David; Bikhet, Mohamed; Ayares, David; Yamamoto, Takayuki; Hara, Hidetaka and Cooper, David KC. "The Genetically Engineered Heart as a Bridge to Allotransplantation in Infants Just Around the Corner?" The Annals of Thoracic Surgery 114(2):536-544

The research study reported here was carried out in 2019 and 2020, and took place at the Department of Surgery, University of Alabama in Birmingham. One of the authors is from Revivicor in Virginia, a company involved in regenerative medicine using alternative tissue sources for treatment of human degenerative disease. Revivicor provided two of the pig hearts. Despite this, there is no 'conflict of interest' statement in the publication, something that is normally required. The only financial support referenced in the article is NIH grant P40 OD024628-01 for the institution that provided the baboons (Michael E. Keeling Center). As of 2021-07-05, the amount of public funds awarded through this grant was $1,892,804. See elsewhere for more information.

2022-07-01: Barra, Beatrice; Conti, Sara; Perich, Matthew G.; Zhuang, Katie; Schiavone, Giuseppe; Fallegger, Florian; Galan, Katia; James, Nicholas D.; Barraud, Quentin; Delacombaz, Maude; Kaeser, Mélanie; Rouiller, Eric M.; Milekovic, Tomislav; Lacour, Stephanie; Bloch, Jocelyne; Courtine, Grégoire and Capogrosso, Marco "Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys" Nature Neuroscience 25(7):924-934

See elsewhere for more information.

2022-06-01: Benton, Mary Lauren; Jimenez, Vanessa A.; Newman, Natali; Gonzales, Steven W.; Grant, Kathleen A.; Turner, Russell T.; Iwaniec, Urszula T. and Baker, Erich J. "Dose-response effects of alcohol on biochemical markers of bone turnover in non-human primates: Effects of species, sex and age of onset of drinking" Bone Reports 16:101159

See elsewhere for more information.

2022-04-01: "Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates" Kiguchi, Norikazu; Ding, Huiping; Park, Sun H.; Mabry, Kelsey M.; Kishioka, Shiroh; Shiozawa, Yusuke; Romero-Sandoval, E. Alfonso; Peters, Christopher M. and Ko, Mei-Chuan Biochemical Pharmacology 198:114972

In this deplorable publicly funded experiment carried out at Wake Forest School of Medicine, Winston-Salem, NC, six rhesus macaques, four males and two females, aged 10-16 years, had their lives taken from them in an experiment to look at the neurotransmission of itch and pain in non-human primates. See elsewhere for more information.

2022-04-01: "Chronic exposure to delta-9-tetrahydrocannabinol impacts testicular volume and male reproductive health in rhesus macaques" Hedges, Jason C.; Hanna, Carol B.; Bash, Jasper C.; Boniface, Emily R.; Burch, Fernanda C.; Mahalingaiah, Shruthi; Roberts, Victoria H.J.; Terrobias, Juanito Jose D.; Mishler, Emily C.; Jensen, Jared V.; Easley, Charles A. and Lo, Jamie O. Fertility and Sterility 117(4):698-707

Six adult male rhesus macaques were forced to become heavy users of marijuana in this research carried out at the Oregon National Primate Research Center, Oregon Health & Science University. The research was approved by its Institutional Animal Care and Use Committee and supported almost entirely with public funds (NIH and its branches). See elsewhere for more information.

2022-03-01: Allen, Daicia C.; Jimenez, Vanessa A.; Carlson, Timothy L.; Walter, Nicole A.; Grant, Kathleen A. and Cuzon Carlson, Verginia C. "Characterization of DREADD receptor expression and function in rhesus macaques trained to discriminate ethanol" Neuropsychopharmacology 47(4):857-865

See elsewhere for more information.

2022-03-01: Moore, Sharon; Radunskaya, Ami; Zollinger, Elizabeth; Grant, Kathleen A.; Gonzales, Steven; Walter, Nicole A.R. and Baker, Erich J. "Pairing food and drink: A physiological model of blood ethanol levels for a variety of drinking behaviors" Mathematical Biosciences 345:108778

See elsewhere for more information.

2022-03-01: Patel, Reesha R.; Varodayan, Florence P.; Herman, Melissa A.; Jimenez, Vanessa; Agnore, Rebecca; Gao, Lina; Bajo, Michal; Cuzon Carlson, Verginia C.; Walter, Nicole A.; Fei, Suzanne S.; Grant, Kathleen A. and Roberto, Marisa "Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques" Neuropsychopharmacology 47(4):847-856

See elsewhere for more information.

2022-01-01: Cuzon Carlson, Verginia C.; Aylwin, Carlos F.; Carlson, Timothy L.; Ford, Matthew; Mesnaoui, Houda; Lomniczi, Alejandro; Ferguson, Betsy and Cervera-Juanes, Rita P. "Neurobeachin, a promising target for use in the treatment of alcohol use disorder" Addiction Biology 27(1):e13107

See elsewhere for more information.

2022-01-01: Lo, Jamie O.; Schabel, Matthias C.; Roberts, Victoria H.J.; Morgan, Terry K.; Fei, Suzanne S.; Gao, Lina; Ray, Karina G.; Lewandowski, Katherine S.; Newman, Natali P.; Bohn, Jacqueline A.; Grant, Kathleen A.; Frias, Antonio E. and Kroenke, Christopher D. "Effects of early daily alcohol exposure on placental function and fetal growth in a rhesus macaque model" American Journal of Obstetrics and Gynecology 226(1):130.e1-130.e11

See elsewhere for more information.

You can find out more information on all grants made by the National Institutes of Health, the largest funding entity in the US, and all their agencies by using the NIH RePORTER. You can search by grant number, investigator, recipient institution and more (see instructions).