Action for Primates

References on Using Human Beings Instead of Non-human Primates

The following are just a few references that involve people for studies that are being conducted on non-human primates, sometimes concurrently in the same report of a study – calling into question why the non-human primates were used – and sometimes demonstrating substantive differences between the species. These provide evidence to argue against the need for non-human primates when the researchers are getting the same information from ethical studies involving people. They are listed alphabetically by first author.

• Abbasi, Armina; Joswig-Jones, Carolyn A. and Jones. Jeffrey P. 2020-12-01 "Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey" Drug Metabolism and Disposition 48(12):1364-1371

Although they have as much as 95.1% sequence identity, human and cynomolgus monkey aldehyde oxidase are kinetically distinct. Therefore, monkeys may not be good estimators of drug clearance in humans.

• Alarcon, Pedro A.; Tressler, Randall L.; Mulvaney, Anthony; Lam, Wayne and Comer, Gail M. 2020-06-01 "Gastrointestinal tolerance of a new infant milk formula in healthy babies: an international study conducted in 17 countries" Nutrition 18(6):484-489
• Alefantis, Panos; Lakshminarasimhan, Kaushik J.; Avila, Eric; Noel, Jean-Paul; Pitkow, Xaq and Angelaki, Dora E. 2022-07-06 "Sensory evidence accumulation using optic flow in a naturalistic navigation task" The Journal of Neuroscience 42(27):5451-5462
• Alexander, Daniel C.; Hubbard, Penny L.; Hall, Matt G.; Moore, Elizabeth A.; Ptito, Maurice; Parker, Geoff J.M. and Dyrby, Tim B. 2010-10-01 "Orientationally invariant indices of axon diameter and density from diffusion MRI" NeuroImage 52(4):1374-1389

Test data sets for in vivo imaging come from two healthy human volunteers.
Monkey data sets come from two normal appearing young-adult female vervet monkey (Chlorocebus aethiops) brains with matched age of 32 months.

• Alvarado, Diego; Maurer, Marcus; Gedrich, Richard; Seibel, Scott B.; Murphy, Michael B.; Crew, Linda; Goldstein, Joel; Crocker, Andrea; Vitale, Laura A.; Morani, Pamela A.; Thomas, Lawrence J.; Hawthorne, Thomas R.; Keler, Tibor; Young, Diane; Crowley, Elizabeth; Kankam, Martin and Heath-Chiozzi, Margo 2022-08-01 "The anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study" Allergy 77(8):2393-2403

...administration to healthy human subjects was generally well tolerated

• Alves, Arthur Daniel Rocha; Langella, Barbara Barbosa; Lima, Mariana Magaldi de Souza; Coelho, Wagner Luís da Costa Nunes Pimentel; Garcia, Rita de Cássia Nasser Cubel; Cardoso, Claudete Aparecida Araújo; Marchevsky, Renato Sergio; Pinto, Marcelo Alves and Amado, Luciane Almeida 2022-04-18 "Evaluation of Molecular Test for the Discrimination of "Naked" DNA from Infectious Parvovirus B19 Particles in Serum and Bone Marrow Samples" Viruses 14(4):843
• Amore, Benny M.; Cramer, Clay T.; MacDougall, Diane E.; Sasiela, William J. and Emery, Maurice G. 2021-08-31 "Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers" Clinical and Translational Science
• Aravamuthan, B.R.; Stein, J.F. and Aziz, T.Z. 2008-01-01 "The anatomy and localization of the pedunculopontine nucleus determined using probabilistic diffusion tractagrophy" British Journal of Neurosurgery 22(s1):S25-S32
• Arcaro, Michael J.; Livingstone, Margaret S.; Kay, Kendrick N. and Weiner, Kevin S. 2021-12-17 "The retrocalcarine sulcus maps different retinotopic representations in macaques and humans" Brain Structure & Function

Yet, across species, the underlying eccentricity representations corresponding to these macroanatomical structures differ strikingly across humans and macaques. Thus, the correspondence between retinotopic representation and cortical folding for an evolutionarily old structure like V1 is species-specific and suggests potential differences in developmental and experiential constraints across primates.

• Atack, J.R.; Hallett, D.J.; Tye, S.; Wafford, K.A.; Ryan, C.; Sanabria-Bohorquez, S.M.; Eng, Wai-si; Gibson, R.E.; Burns, H.D.; Dawson, G.R.; Carling, R.W.; Street, L.J.; Pike, A.; De Lepeleire, I.; Van Laere, K.; Bormans, G.; de Hoon, J.N.; Van Hecken, A.; McKernan, R.M.; Murphy, M.G. and Hargreaves, R.J. 2011-03-01 "Preclinical and clinical pharmacology of TPA023B, a GABAA receptor a2/a3 subtype-selective partial agonist" Journal of Psychopharmacology 25(3):329-344
• Balslev, Daniela; Mitchell, Alexandra G.; Faria, Patrick J.M.; Priba, Lukasz and Macfarlane, Jennifer A. 2022-09-22 "Proprioceptive contribution to oculomotor control in humans" Human Brain Mapping

Unlike macaques, humans possess numerous muscle spindles in their EOMs [extraocular muscles]. To find out whether the human oculomotor nuclei respond to proprioceptive feedback we used functional magnetic resonance imaging (fMRI).

• Barbosa, Joao; Stein, Heike; Martinez, Rebecca L.;Galan-Gadea, Adrià; Li, Sihai; Dalmau, Josep; Adam, Kirsten C.S.; Valls-Solé, Josep; Constantinidis, Christos and Compte, Albert 2020-08-01 "Interplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory" Nature Neuroscience 23(8):1016-1024

Thirty-five (35) neurologically and psychologically healthy volunteers with normal or corrected vision...

• Barraclough, Nick E.; Keith, Rebecca H.; Xiao, Dengke; Oram Mike W. and Perrett, David I. 2009-09-01 "Visual adaptation to goal-directed hand actions" Journal of Cognitive Neuroscience 21(9):1806-1819
• Barrett, Rachel L.C.; Dawson, Matthew; Dyrby, Tim B.; Krug, Kristine; Ptito, Maurice; D'Arceuil, Helen; Croxson, Paula L.; Johnson, Philippa J.; Howells, Henrietta; Forkel, Stephanie J.; Dell'Acqua, Flavio and Catani, Marco 2020-03-04 "Differences in Frontal Network Anatomy Across Primate Species" The Journal of Neuroscience 40(10):2094-2107
• Baruch, Amos; Wong, Chin; Chinn, Leslie W.; Vaze, Anjali; Sonoda, Junichiro; Gelzleichter, Thomas; Chen, Shan; Lewin-Koh, Nicholas; Morrow, Linda; Dheerendra, Suresh; Boismenu, Richard; Gutierrez, Johnny; Wakshull, Eric; Wilson, Maria E. and Arora, Puneet S. 2020-11-17 "Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans" Proceedings of the National Academy of Sciences of the United States of America 117(46):28992-29000

A clinical study in overweight human participants demonstrated that a single dose of BFKB8488A caused transient body weight reduction, sustained improvement in cardiometabolic parameters, and a trend toward reduction in preference for sweet taste and carbohydrate intake.

• Belin, Pascal; Fecteau, Shirley; Charest, Ian; Nicastro, Nicholas; Hauser, Marc D. and Armony, Jorge L. 2008-03-07 "Human cerebral response to animal affective vocalizations" Proceedings. Biological Sciences 275(1634):473-481
• Beuriat, Pierre-Aurélien; Cristofori, Irene; Richard, Nathalie; Bardi, Lara; Loriette, Celia; Szathmari, Alexandru; Di Rocco, Federico; Leblond, Pierre; Frappaz, Didier; Faure-Conter, Cécile; Claude, Line; Mottolese, Carmine and Desmurget, Michel 2020-03-06 "Cerebellar lesions at a young age predict poorer long-term functional recovery" Brain Communications 2(1):fcaa027

We studied the impact or early cerebellar damage on long-term functional recovery in three groups of 15 posterior fossa survivors, comparable with respect to their tumour characteristics (type, size and location) but operated at different ages...

• Bodin, Clémentine; Trapeau, Régis; Nazarian, Bruno; Sein, Julien; Degiovanni, Xavier; Baurberg, Joël; Rapha, Emilie; Renaud, Luc; Giordano, Bruno L. and Belin, Pascal 2021-09-09 "Functionally homologous representation of vocalizations in the auditory cortex of humans and macaques" Current Biology S0960-9822(21):01147-7
• Breveglieri, Rossella; Borgomaneri, Sara; Filippini, Matteo; Tessari, Alessia; Galletti, Claudio; Davare, Marco and Fattori, Patrizia 2022-10-15 "Complementary contribution of the medial and lateral human parietal cortex to grasping: a repetitive TMS study" Cerebral Cortex bhac404

To elucidate the causal role of phAIP and hV6A, we stimulated these areas, while participants were performing grasping actions (unperturbed grasping). ... These results represent the first direct demonstration of a different encoding of grasping parameters by 2 grasp-related parietal areas.

• Cai, Dan-Chao; Wang, Zhiwei; Bo, Tingting; Yan, Shengyao; Liu, Yilin; Liu, Zhaowen; Zeljic, Kristina; Chen, Xiaoyu; Zhan, Yafeng; Xu, Xiu; Du, Yasong; Wang, Yingwei; Cang, Jing; Wang, Guang-Zhong; Zhang, Jie; Sun, Qiang; Qiu, Zilong; Ge, Shengjin; Ye, Zheng and Wang, Zheng 2021-05-06 "MECP2 Duplication Causes Aberrant GABA Pathways, Circuits and Behaviors in Transgenic Monkeys: Neural Mappings to Patients with Autism" The Journal of Neuroscience 40(19):3799-3814

Furthermore, we stratified a cohort of 49 patients with autism and 72 healthy controls of 1112 subjects using functional connectivity patterns, and identified dysconnectivity profiles similar to those in monkeys.

• Caviola, L.; Kahane, G.; Everett, J.A.C.; Teperman, E.; Savulescu, J. and Faber, N.S. 2021-05-01 "Utilitarianism for animals, Kantianism for people? Harming animals and humans for the greater good" Journal of Experimental Psychology. General 150(5):1008-1039
• Cendrowicz, Ewa; Jacob, Lisa; Greenwald, Shirley; Tamir, Ami; Pecker, Iris; Tabakman, Rinat; Ghantous, Lucy; Tamir, Liat; Kahn, Roy; Avichzer, Jasmine; Aronin, Alexandra; Amsili, Shira; Zorde-Khvalevsky, Elina; Gozlan, Yosi; Vlaming, Martijn; Huls, Gerwin; van Meerten, Tom; Dranitzki, Michal Elhalel; Foley-Comer, Adam; Pereg, Yaron; Peled, Amnon; Chajut, Ayelet and Bremer, Edwin 2022-03-14 "DSP107 combines inhibition of CD47/SIRPa axis with activation of 4-1BB to trigger anticancer immunity" Journal of Experimental & Clinical Cancer Research 41(1):97
• Chang, Xiao L.; Reed, Jason S.; Webb, Gabriela M.; Wu, Helen L.; Le, Jimmy; Bateman, Katherine B.; Greene, Justin M.; Pessoa, Cleiton; Waytashek, Courtney; Weber, Whitney C.; Hwang, Joseph; Fischer, Miranda; Moats, Cassandra; Shiel, Oriene; Bochart, Rachele M.; Crank, Hugh; Siess, Don; Giobbi, Travis; Torgerson, Jeffrey; Agnor, Rebecca; Gao, Lina; Dhody, Kush; Lalezari, Jacob P.; Bandar, Ivo Sah; Carnate, Alnor M.; Pang, Alina S.; Corley, Michael J.; Kelly, Scott; Pourhassan, Nader; Smedley, Jeremy; Bimber, Benjamin N.; Hansen, Scott G.; Ndhlovu, Lishomwa C. and Sacha, Jonah B. 2022-03-31 "Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species" PLoS Pathogens 18(3):e1010396
• Charvet, Christine J.; Ofori, Kwadwo; Baucum, Christine; Sun, Jianli; Modrell, Melinda S.; Hekmatyar, Khan; Edlow, Brian L. and van der Kouwe, Andre J. 2022-05-04 "Tracing Modification to Cortical Circuits in Human and Nonhuman Primates from High-Resolution Tractography, Transcription, and Temporal Dimensions" The Journal of Neuroscience 42(18):3749-3767
• Chassen, Stephanie Skuby; Ferchaud-Roucher, Veronique; Gupta, Madhulika B.; Jansson, Thomas and Powell, Theresa L. 2018-03-15 "Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction" Clinical Science (London, England : 1979) 132(5):595-607
• Cheng, Luqi; Zhang, Yuanchao; Li, Gang; Wang, Jiaojian; Sherwood, Chet; Gong, Gaolang; Fan, Lingzhong and Jiang, Tianzi 2021-07-02 "Connectional asymmetry of the inferior parietal lobule shapes hemispheric specialization in humans, chimpanzees, and rhesus macaques" eLife 10:e67600
• Chung, Daniel W.; Geramita, Matthew A. and Lewis, David A. 2022-04-01 "Synaptic Variability and Cortical Gamma Oscillation Power in Schizophrenia" The American Journal of Psychiatry 179(4):277-287

This alteration was not influenced by schizophrenia-associated comorbid factors, was not present in monkeys chronically exposed to antipsychotic medications, and was not present in calretinin interneurons.

• Civelek, Zeynep; Völter, Christoph J. and Seed, Amanda M. 2021-08-04 "What happened? Do preschool children and capuchin monkeys spontaneously use visual traces to locate a reward?" Proceedings. Biological Sciences / The Royal Society 288(1956):20211101
• Cole, M.W. ; Yeung, N. ; Freiwald, W.A. and Botvinick, M. 2010-08-01 "Conflict over cingulate cortex: Between-species differences in cingulate may support enhanced cognitive flexibility in humans" Brain, Behavior and Evolution 75(4):239-240
• Cowey, Alan; Alexander, Iona and Stoerig, Petra 2011-07-01 "Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans" Brain 134(7):2149-2157
• Curran, William and Lynn, Catherine 2009-12-23 "Monkey and humans exhibit similar motion-processing mechanisms" Biology Letters 5(6):743-745
• Cuzon Carlson, Verginia C.; Aylwin, Carlos F.; Carlson, Timothy L.; Ford, Matthew; Mesnaoui, Houda; Lomniczi, Alejandro; Ferguson, Betsy and Cervera-Juanes, Rita P. 2022-01-01 "Neurobeachin, a promising target for use in the treatment of alcohol use disorder" Addiction Biology 27(1):e13107

Tissue from patients with alcohol use disorder were obtained and compared with the macaque tissue.

• Dias, Pedro Américo D.; Coyohua-Fuentes, Alejandro; Canales-Espinosa, Domingo and Rangel-Negrín, Ariadna 2022-11-08 "Demography and life-history parameters of mantled howler monkeys at La Flor de Catemaco: 20 years post-translocation" Primates; Journal of Primatology

...Nine individuals belonging to two social groups living in areas that were going to be destroyed were released into La Flor de Catemaco between 2002 and 2004. ... The growth and persistence of the groups at the site, as well as similarity in demographic and life-history parameters between this and unmanaged populations, suggest that mantled howler monkeys living at La Flor de Catemaco represent a stable population and thus that this was a successful translocation.

• Dreyer, Alexander M. and Rieger, Jochem W. 2021-12-02 "High-gamma mirror activity patterns in the human brain during reach-to-grasp movement observation, retention, and execution—An MEG study" PLoS One 16(12):e0260304
• Du,Yongrui; Carranza, Zaira; Luan, Yi; Busman-Sahay, Kathleen; Wolf, Shally; Campbell, Shawn P.; Kim, So-Youn; Pejovic, Tanja; Estes, Jacob D.; Zelinski, Mary and Xu, Jing 2022-01-31 "Evidence of cancer therapy-induced chronic inflammation in the ovary across multiple species: A potential cause of persistent tissue damage and follicle depletion" Journal of Reproductive Immunology 150:103491

Blood and ovarian samples were collected from reproductive age women, rhesus macaques, and mice after completion of chemotherapy and/or radiotherapy and from age-matched patients and animals without chemotherapy agent or radiation exposure to serve as controls.

• Duque-Díaz, Ewing and Coveñas, Rafael 2021-05-10"Mapping of folic acid in the children brainstem" Anatomy & Cell Biology

The distribution of FA in the central nervous system of humans and monkeys is different and, in addition, in these species the vitamin was located in different parts of the nerve cells.

• Farcas, Ruxandra; Schneider, Eberhard; Frauenknecht, Katrin; Kondova, Ivanela; Bontrop, Ronald; Bohl, Jürgen; Navarro, Bianca; Metzler, Markus; Zischler, Hans; Zechner, Ulrich; Daser, Angelika and Haaf, Thomas 2009-06-01 "Differences in DNA methylation patterns and expression of the CCRK gene in human and nonhuman primate cortices" Molecular Biology and Evolution 26(6):1379-1389

Brain samples were obtained between 1 and 2 days postmortem from 12 humans...

• Fehring, Daniel J.; Pascoe, Alexander J.; Haque, Zakia Z.; Samandra, Ranshikha; Yokoo, Seiichirou; Abe, Hiroshi; Rosa, Marcello G.P.; Tanaka, Keiji; Yamamori, Tetsuo and Mansouri, Farshad A. 2022-03-29"Dimension of visual information interacts with working memory in monkeys and humans" Scientific Reports 12(1):5335
• Felsche, Elisa; Stevens, Patience; Völter, Christoph J.; Buchsbaum, Daphna and Seed, Amanda M. 2022-12-08 "Evidence for abstract representations in children but not capuchin monkeys" Cognitive Psychology 140:101530

Children's choices were consistent with the model predictions and thus suggest an ability for abstract knowledge formation in the preschool years, whereas monkeys performed at chance level.

• Fisher, Karen M.; Zaaimi, Boubker; Williams, Timothy L.; Baker, Stuart N. and Baker, Mark R. 2012-09-01 "Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease" Brain 135(9):2849-2864

Human patients who had brain lesions were used.

• Flessert, M.; Taubert, J. and Beran, M.J. 2022-07-14 "Assessing the perception of face pareidolia in children (Homo sapiens), rhesus monkeys (Macaca mulatta), and capuchin monkeys (Sapajus apella)" Journal of Comparative Psychology

We presented a novel computerized task to capuchin monkeys (Sapajus apella), rhesus monkeys (Macaca mulatta), and preschool-aged children (Homo sapiens). This task trained subjects to choose faces over nonface images, and then presented pareidolia images with nonface images. All species selected faces most often on trials that included face images. However, only children selected pareidolia images at levels above chance. These results indicate that while children report perceiving face pareidolia, monkeys do not.

• Forbes, Patrick A.; Kwan, Annie; Rasman, Brandon G.; Mitchell, Diana E.; Cullen, and Blouin, Jean-Sébastien 2020-02-26 "Neural Mechanisms Underlying High-Frequency Vestibulocollic Reflexes In Humans And Monkeys" The Journal of Neuroscience 40(9):1874-1887
• Foysal, K.M. Riashad; de Carvalho, Felipe and Baker, Stuart N. 2016-10-19 "Spike Timing-Dependent Plasticity in the Long-Latency Stretch Reflex Following Paired Stimulation from a Wearable Electronic Device" The Journal of Neuroscience 36(42):10823-10830

Here we attempted to induce plastic changes in the LLSR [long-latency stretch reflex] by pairing noninvasive stimuli that are known to activate reticulospinal pathways, at timings predicted to cause spike timing-dependent plasticity in the brainstem. In healthy human subjects, reflex responses in flexor muscles were recorded following extension perturbations at the elbow.

• Fragaszy, D.M.; Lukemire, J.D.; Reynoso-Cruz, J.E.; Villarreal Jordan, S.; Sheheane, S.; Heaton, A.; Quinones, M. and Mangalam, M. 2021-08-01 "How tufted capuchin monkeys (Sapajus spp.) and humans (Homo sapiens) handle a jointed tool" Journal of Comparative Psychology 135(3):382-393

We tested predictions from this theory by studying how 3 tufted capuchin monkeys (Sapajus spp.) and 6 humans (Homo sapiens) used a hoe to retrieve a token.

• Fraser, Helen C.; Kuan, Valerie; Johnen, Ronja; Zwierzyna, Magdalena; Hingorani, Aroon D.; Beyer, Andreas and Partridge, Linda 2022-03-08 "Biological mechanisms of aging predict age-related disease co-occurrence in patients" Aging Cell e13524
• Garin, Clément M.; Hori, Yuki; Everling, Stefan; Whitlow, Christopher T.; Calabro, Finnegan J.; Luna, Beatriz; Froesel, Mathilda; Gacoin, Maëva; Ben Hamed, Suliann; Dhenain, Marc and Constantinidis, Christos 2022-04-12 "An evolutionary gap in primate default mode network organization" Cell Reports 39(2):110669

Here, based on a cross-species comparison of the DMN [default mode network] between humans and non-hominoid primates (macaques, marmosets, and mouse lemurs), we report major dissimilarities in connectivity profiles. Most importantly, the medial prefrontal cortex (mPFC) of non-hominoid primates is poorly engaged with the posterior cingulate cortex (PCC), though strong correlated activity between the human PCC and the mPFC is a key feature of the human DMN. Instead, a fronto-temporal resting-state network involving the mPFC was detected consistently across non-hominoid primate species. These common functional features shared between non-hominoid primates but not with humans suggest a substantial gap in the organization of the primate's DMN and its associated cognitive functions.

• Gaveau, Jeremie; Grospretre, Sidney; Berret, Bastien; Angelaki, Dora E. and Papaxanthis, Charalambos 2021-04-07 "A cross-species neural integration of gravity for motor optimization" Science Advances 7(15):eabf7800
• Glausier, Jill R.; Enwright, John F. and Lewis, David A. 2020-12-01 "Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder" The American Journal of Psychiatry 177(12):1140-1150
• Gnanateja, G. Nike; Rupp, Kyle; Llanos, Fernando; Remick, Madison; Pernia, Marianny; Sadagopan, Srivatsun; Teichert, Tobias; Abel, Taylor J. and Chandrasekaran, Bharath 2021-11-17 "Frequency-following responses to speech sounds are highly conserved across species and contain cortical contributions" eNeuro
• Gofas-Salas, Elena; Rui, Yuhua; Mecê, Pedro; Zhang, Min; Snyder, Valerie C.; Vienola, Kari V.; Lee, Daniel M.W.; Sahel, José-Alain; Grieve, Kate and Rossi, Ethan A. 2022-01-01 "Design of a radial multi-offset detection pattern for in vivo phase contrast imaging of the inner retina in humans" Biomedical Optics Express 13(1):117-132
• Greiner, Nathan; Barra, Beatrice; Schiavone, Giuseppe; Lorach, Henri; James, Nicholas; Conti, Sara; Kaeser, Melanie; Fallegger, Florian; Borgognon, Simon; Lacour, Stéphanie; Bloch, Jocelyne; Courtine, Grégoire and Capogrosso, Marco 2021-01-19 "Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord" Nature Communications 12(1):435

Human patients with similar spinal surgeries were also tested.

• Guevara, Elaine E.; Hopkins, William D.; Hof, Patrick R.; Ely, John J.; Bradley, Brenda J. and Sherwood, Chet C. 2021-05-06 "Comparative analysis reveals distinctive epigenetic features of the human cerebellum" PLoS Genetics 17(5):e1009506
• Gurgand, Lilas and Beran, Michael J. 2021-01-01 "Assessing consistency in children's and monkeys' performance across computerized and manual detour problem tasks" Behavioural Processes 182:104291
• Han, Leo; Park, Daye; Reddy, Ashok; Wilmarth, Phillip A. and Jensen, Jeffrey T. 2021-05-15 "Comparing endocervical mucus proteome of humans and rhesus macaques" Proteomics. Clinical Applications e2100023
• Hanioka, Nobumitsu; Isobe, Takashi; Tanaka-Kagawa, Toshiko; Jinno, Hideto and Ohkawara, Susumu 2020-11-13 "In vitro glucuronidation of bisphenol A in liver and intestinal microsomes: interspecies differences in humans and laboratory animals" Drug and Chemical Toxicology

These results suggest that the functional roles of UDP-glucuronosyltransferase (UGT) enzymes expressed in the liver and intestines in the metabolism of BPA extensively differ among humans, monkeys, dogs, rats, and mice.

• Hanioka, Nobumitsu; Saito, Keita; Isobe, Takashi; Ohkawara, Susumu; Jinno, Hideto and Tanaka-Kagawa, Toshiko 2021-03-22 "Favipiravir biotransformation in liver cytosol: Species and sex differences in humans, monkeys, rats, and mice" Biopharmaceutics & Drug Disposition

This suggests that the roles of aldehyde oxidase in the hepatic metabolism of favipiravir differ extensively depending on the species and sex...

• Hansen, Heather A.; Li, Jin and Saygin, Zeynep M. 2020-10-19 "Adults vs. neonates: Differentiation of functional connectivity between the basolateral amygdala and occipitotemporal cortex" PLoS One 15(10):e0237204

Forty neonates (15 female, 25 male; mean gestational age at birth = 38.99 weeks, gestational age range at scan = 37–44 weeks) were obtained from the initial release of the Developing Human Connectome Project (dHCP, http://www.developingconnectome.org) [40]. ... Forty adults (15 female, 25 male; age range 22–36 years) were obtained from the Human Connectome Project (HCP), WU-Minn HCP 1200 Subjects Data Release (https://www.humanconnectome.org/study/hcp-young-adult) [41].

• Hanus, D.; Truppa, V. and Call, J. 2022-10-31 "Are you as fooled as I am? Visual illusions in human (Homo) and nonhuman (Sapajus, Gorilla, Pan, Pongo) primate species" Journal of Comparative Psychology
• Härtner, J.; Strauss, S.; Pfannmőller, J. and Motze, M. 2021-05-15 "Tactile acuity of fingertips and hand representation size in human Area 3b and Area 1 of the primary somatosensory cortex" NeuroImage 232:117912

We here applied repetitive pneumatic stimulation of digit 1 (D1; thumb) and digit 5 (D5; little finger) on both hands to investigate finger/hand representation maps in the complete S1, but also in cytoarchitectonic Areas 1, 2, 3a, and 3b separately, in 21 healthy volunteers using 3T fMRI.

• Hayashi, Misato and Takeshita, Hideko 2022-09-01 "Hierarchical object combination and tool use in the great apes and human children" Primates; Journal of Primatology 63(5):429-441
• Henry, Christopher A. and Kohn, Adam 2020-04-03 "Spatial contextual effects in primary visual cortex limit feature representation under crowding" Nature Communications 11(1):1687
• Hirter, Kristen N.; Miller, Elaine N.; Stimpson, Cheryl D.; Phillips, Kimberley A.; Hopkins, William D.; Hof, Patrick R.; Sherwood, Chet C.; Lovejoy, C. Owen and Raghanti, Mary Ann 2021-05-25 "The nucleus accumbens and ventral pallidum exhibit greater dopaminergic innervation in humans compared to other primates" Brain Structure & Function

Our data show that humans have a significantly greater dopaminergic innervation in both structures...

• Hogeveen, Jeremy; Mullins, Teagan S.; Romero, John D.; Eversole, Elizabeth; Rogge-Obando, Kimberly; Mayer, Andrew R. and Costa, Vincent D. 2022-03-30 "The neurocomputational bases of explore-exploit decision-making" Neuron S0896-6273(22)00250-1

We then used fMRI to identify where in the human brain the immediate value of exploitative choices and relative uncertainty about the value of exploratory choices were encoded. ... These results clarify the interplay between prefrontal and motivational circuits that supports adaptive explore-exploit decisions in humans...

• Honda, Shiori; Fukami, Tatsuki; Hirosawa, Keiya; Tsujiguchi, Takuya; Zhang, Yongjie; Nakano, Masataka; Uehara, Shotaro; Uno, Yasuhiro; Yamazaki, Hiroshi and Nakajima, Miki 2021-06-16 "Differences in hydrolase activities in the liver and small intestine between marmosets and humans" Drug Metabolism and Disposition : The Biological Fate of Chemicals

This study confirmed that there are large differences in hydrolase activities between humans and marmosets...The data obtained in this study may be useful for considering whether marmosets are appropriate for examining the pharmacokinetics and efficacies of new chemical entities in preclinical studies.

• Hori, Yuki; Cléry, Justine C.; Selvanayagam, Janahan; Schaeffer, David J.; Johnston, Kevin D.; Menon, Ravi S. and Everling, Stefan 2021-09-14 "Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas" Proceedings of the National Academy of Sciences of the United States of America 118(37):e2110980118
• Hori, Yuki; Schaeffer, David J.; Yoshida, Atsushi; Cléry, Justine C.; Hayrynen, Lauren K.; Gati, Joseph S.; Menon, Ravi S. and Everling, Stefan 2020-11-25 "Cortico-Subcortical Functional Connectivity Profiles of Resting-State Networks in Marmosets and Humans" The Journal of Neuroscience 40(48):9236-9249

While we could match several marmoset and human resting-state networks based on their functional fingerprints, we also found a few striking differences, for example, strong functional connectivity of the default mode network with the superior colliculus in marmosets that was much weaker in humans. Together, these findings demonstrate that many of the core cortico-subcortical networks in humans are also present in marmosets, but that small, potentially functionally relevant differences exist.

• Hsu, Tzu-Yu; Chen, Jui-Tai; Tseng, Philip and Wang, Chin-An 2021-10-01 "Role of the frontal eye field in human microsaccade responses: A TMS study" Biological Psychology 165:108202
• Hsu, Tzu-Yu; Hsu, Yu-Fan; Wang, Hsin-Yi and Wang, Chin-An 2021-04-26 "Role of the frontal eye field in human pupil and saccade orienting responses" The European Journal of Neuroscience
• Hsu, Tzu-Yu; Wang, Hsin-Yi; Chen, Jui-Tai and Wang, Chin-An 2022-11-17 "Investigating the role of human frontal eye field in the pupil light reflex modulation by saccade planning and working memory" Frontiers in Human Neuroscience 16:1044893

Together, our results constitute the first evidence of [frontal eye field] modulation in human pupil local-luminance responses.

• Hu, Youjin; Huang, Kevin; Zeng, Qiao; Feng, Yun; Ke, Qiong; An, Qin; Qin, Lian-Ju; Cui, YuGui; Guo, Ying; Zhao, Dicheng; Peng, Yu; Tian, Di; Xia, Kun; Chen, Yong; Ni, Bin; Wang, Jinmei; Zhu, Xianmin; Wei, Lai; Liu, Yizhi; Xiang, Peng; Liu, Jia-Yin; Xue, Zhigang and Fan, Guoping 2021-07-01 "Single-cell analysis of nonhuman primate preimplantation development in comparison to humans and mice" Developmental Dynamics 250(7):974-985
• Huang, Fei-Yang; Sutcliffe, Michael P.F. and Grabenhorst, Fabian 2021-06-29 "Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys" Proceedings of the National Academy of Sciences of the United States of America 118(26):e2101954118

...we performed a psychophysical experiment in which human participants (n = 23) sampled the liquids used in the monkey experiments and rated subjective perceptions of the mouthfeel produced by the liquids...

• Huang, Felicia Scaggs; Bernstein, David I.; Slobod, Karen S.; Portner, Allen; Takimoto, Toru; Russell, Charles J.; Meagher, Michael; Jones, Bart G.; Sealy, Robert E.; Coleclough, Christopher; Branum, Kristen; Dickey, Michelle; Buschle, Kristen; McNeal, Monica; Makowski, Mat; Nakamura, Aya and Hurwitz, Julia L. 2020-08-04 "Safety and immunogenicity of an intranasal sendai virus-based vaccine for human parainfluenza virus type I and respiratory syncytial virus (SeVRSV) in adults" Human Vaccines & Immunotherapeutics 17(2):554-559

Seventeen and four healthy adults received intranasal SeVRSV and PBS, respectively, followed by six months of safety monitoring.

• Hur, Juyoen; Kuhn, Manuel; Grogans, Shannon E.; Anderson, Allegra S.; Islam, Samiha; Kim, Hyung Cho; Tillman, Rachael M.; Fox, Andrew S.; Smith, Jason F.; DeYoung, Kathryn A. and Shackman, Alexander J. 2022-06-03 "Anxiety-Related Frontocortical Activity Is Associated With Dampened Stressor Reactivity in the Real World" Psychological Science 9567976211056635

Here, we used a combination of approaches–including neuroimaging assays of threat anticipation and emotional-face perception and more than 10,000 momentary assessments of emotional experience–to demonstrate that individuals who showed greater activation in a cingulo-opercular circuit during an anxiety-eliciting laboratory paradigm experienced lower levels of stressor-dependent distress in their daily lives (ns = 202–208 university students).

• Iida, Hiroyuki; Komagata, Tatsuya; Tanaka, Hirotaka; Nagasawa, Ryusuke; Nishio, Takuya; Shono, Tomoyuki; Kitagawa, Junsaku; Ogawara, Ken-ichi; Shinozaki, Koji; Seki, Akiteru; Bruce, Mark and Ohno, Tomoya 2021-10-01 "Novel Platform for Predicting Drug Effects in Patients with Acromegaly: Translational Exposure-Response Evaluation of Growth Hormone-Inhibitory Effect of Octreotide Following Growth Hormone-Releasing Hormone Stimulation" The Journal of Pharmacology and Experimental Therapeutics
• Imai, Mutsumi; Murai, Chizuko; Miyazaki, Michiko; Okada, Hiroyuki and Tomonaga, Masaki 2021-09-01 "The contingency symmetry bias (affirming the consequent fallacy) as a prerequisite for word learning: A comparative study of pre-linguistic human infants and chimpanzees" Cognition 214:104755
• Iturria-Medina, Yasser; Fernández, Alejandro Pérez; Morris, David M.; Canales-Rodríguez, Erick J.; Haroon, Hamied A.; Pentón, Lorna García; Augath, Mark; García, Lídice Galán; Logothetis, Nikos; Parker, Geoffrey J.M. and Melie-García, Lester 2011-01-01 "Brain hemispheric structural efficiency and interconnectivity rightward asymmetry in human and nonhuman primates" Cerebral Cortex 21(1):56-67
• Iwasaki, Shinji; Zhu, Andy; Hanley, Michael; Venkatakrishnan, Karthik and Xia, Cindy 2020-04-14 "A Translational Physiologically Based Pharmacokinetics/Pharmacodynamics Framework of Target-Mediated Disposition, Target Inhibition and Drug–Drug Interactions of Bortezomib" The AAPS Journal 22(3):66
• Jbabdi, Saad; Lehman, Julia F.; Haber, Suzanne N. and Behrens, Timothy E. 2013-02-13 "Human and monkey ventral prefrontal fibers use the same organizational principles to reach their targets: Tracing versus tractography" The Journal of Neuroscience 33(7):3190-3201
• Jenkins, Aaron K.; Lewis, David A. and Volk, David W. 2023-01-01 "Altered expression of microglial markers of phagocytosis in schizophrenia" Schizophrenia Research 251:22-29
• Johansson, Pia A.; Brattås, Per Ludvik; Douse, Christopher H.; Hsieh, PingHsun; Adami, Anita; Pontis, Julien; Grassi, Daniela; Garza, Raquel; Sozzi, Edoardo; Cataldo, Rodrigo; Jönsson, Marie E.; Atacho, Diahann A.M.; Pircs, Karolina; Eren, Feride; Sharma, Yogita; Johansson, Jenny; Fiorenzano, Alessandro; Parmar, Malin; Fex, Malin; Trono, Didier; Eichler, Evan E.; and Jakobsson, Johan 2021-10-07 "A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development" Cell Stem Cell S1934-5909(21):00384-2

ZNF558 is uniquely expressed in human but not chimpanzee forebrain progenitors

• Johnson, Luke A.; Aman, Joshua E.; Yu, Ying; Sanabria, David Escobar; Wang, Jing; Hill, Meghan; Dharnipragada, Rajiv; Patriat, Remi; Fiecas, Mark; Li, Laura; Schrock, Lauren E.; Cooper, Scott E.; Johnson, Matthew D.; Park, Michael C.; Harel, Noam and Vitek, Jerrold L. 2021-06-01 "High-Frequency Oscillations in the Pallidum: A Pathophysiological Biomarker in Parkinson's Disease?" Movement Disorders 36(6):1332-1341

Spontaneous and movement-related GPi field potentials were recorded from DBS leads in 5 externalized PD patients on and off dopaminergic medication, as well as from 3 rhesus monkeys before and after the induction of parkinsonism with the neurotoxin 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine.

• Kawada, Mikaze; Nakatsukasa, Masato; Nishimura, Takeshi; Kaneko, Akihisa; Ogihara, Naomichi; Yamada, Shigehito; Coudyzer, Walter; Zollikofer, Christoph P.E.; Ponce de León, Marcia S. and Morimoto, Naoki 2022-04-19 "Human shoulder development is adapted to obstetrical constraints" Proceedings of the National Academy of Sciences of the United States of America 119(16):e2114935119

Here we address this question by tracking the development of shoulder width from fetal to adult stages in humans, chimpanzees, and Japanese macaques. Compared with nonhuman primates, shoulder development in humans follows a different trajectory, exhibiting reduced growth relative to trunk length before birth and enhanced growth after birth.

• Keller, Simon S.; Roberts, Neil and Hopkins, William 2009-11-18 "A comparative magnetic resonance imaging study of the anatomy, variability, and asymmetry of Broca's area in the human and chimpanzee brain" The Journal of Neuroscience 29(46):14607-14616
• Kesserwani, Hassan 2020-07-28 "The Zeitraffer Phenomenon: A Strategic Ischemic Infarct of the Banks of the Parieto-Occipital Sulcus - A Unique Case Report and a Side Note on the Neuroanatomy of Visual Perception" Cureus 12(7):e9443

We describe the remarkable case of a medically healthy right-handed 15-year-old boy who developed an ischemic infarct of the banks of the right parieto-occipital sulcus (POs). ... We describe the neuroanatomy and neurophysiology of the dorsal visual stream and correlate the localization of this type of infarct in our patient with the known functional neuroanatomy. Although lesional studies in Macaque monkeys and functional MRI studies in humans have documented the clinical-functional correlations of POs lesions and perceived motion deficits, our case is one of the very first human cases in the literature that pinpoints the Zeitraffer phenomenon to a specific and strategic circumscribed ischemic stroke in the region of the POs.

• Kinoshita, Yuki; Goto, Ryosuke; Nakano, Yoshihiko and Hirasaki, Eishi 2021-01-01 "A comparison of axial trunk rotation during bipedal walking between humans and Japanese macaques" American Journal of Physical Anthropology 174(1):66-75

We collected three-dimensional trunk kinematic data during bipedal walking in six humans and five Japanese macaques. The human subjects walked on a treadmill, and the animal subjects walked on a 5-m runway.

• Klein, Johannes C.; Rushworth, Matthew F.S.; Behrens, Timothy E.J.; Mackay, Clare E.; de Crespigny, Alex J.; D'Arceuil, Helen and Johansen-Berg, Heidi 2010-06-01 "Topography of connections between human prefrontal cortex and mediodorsal thalamus studied with diffusion tractography" NeuroImage 51(2):555-564
• Kong, Ronald; Ma, Jiyuan; Beers, Brian; Kaushik, Diksha; Lin, E; Goodwin, Elizabeth; Colacino, Joseph and Bibbiani, Francesco 2020-12-01 "Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort" Pharmacology Research & Perspectives 8(6):e00677

Six healthy male subjects were each administered a single oral dose of 60 mg [14C]-deflazacort. Plasma and urine were collected and deflazacort metabolites in plasma were quantified by high performance liquid chromatography radio-profiling followed by liquid chromatography-mass spectrometry characterization.

• Kong, Xiang-Zhen; Postema, Merel; Schijven, Dick; Castillo, Amaia Carrión; Pepe, Antonietta; Crivello, Fabrice; Joliot, Marc; Mazoyer, Bernard; Fisher, Simon E. and Francks, Clyde 2021-04-09 "Large-Scale Phenomic and Genomic Analysis of Brain Asymmetrical Skew" Cerebral Cortex (New York, N.Y. : 1991) bhab075

These results provide the first large-scale description of population-average brain skews and their inter-individual variations, their replicable associations with handedness, and insights into biological and other factors which associate with human brain asymmetry.

• Konishi, Kentaro; Nakamura, Koji; Hanada, Yuichi; Kitanaga, Yukihiro; Kubo, Satoshi; Kinugasa, Fumitaka; Yamajuku, Daisuke; Maeda, Masashi; Yamamoto, Nobuchika; Minematsu, Tsuyoshi; Ohbuchi, Masato; Kondo, Yuya and Sumida, Takayuki 2022-06-11 "Preclinical Characterization of ASP2713, a Novel Igβ and FcγRIIB Cross-linking Antibody, for Prediction of Human Pharmacokinetics and Clinically Effective Dose" Journal of Pharmaceutical Sciences S0022-3549(22)00250-7
• Konoike, Naho; Iwaoki, Haruhiko; Miwa, Miki; Sakata, Honami; Itoh, Kosuke and Nakamura, Katsuki 2022-06-02 "Comparison of non-invasive, scalp-recorded auditory steady-state responses in humans, rhesus monkeys, and common marmosets" Scientific Reports 12(1):9210
• Kremers, Jan; Aher, Avinash, J.; Parry, Neil R.A.; Patel, Nimesh B. and Frishman, Laura J. 2021-05-01 "Comparison of macaque and human L- and M-cone driven electroretinograms" Experimental Eye Research 206:108556
• Krishnan, Aditya; Agwu, Juliana Chizo; Kallappa, Chetana and Pandey, Rajesh 2021-04-15 "Development of central precocious puberty following cannabinoid use for paediatric epilepsy: causal or coincidence?" BMJ Case Reports 14(4):e239678
• Layman, Hans; Rickert, Keith W.; Wilson, Susan; Aksyuk, Anastasia A.; Dunty, Jill M.; Natrakul, Dusit; Swaminathan, Nithya and DelNagro, Christopher J. 2020-03-26 "Development and validation of a multiplex immunoassay for the simultaneous quantification of type-specific IgG antibodies to E6/E7 oncoproteins of HPV16 and HPV18" PLoS One 15(3):e0229672

Serum from various human donor cohorts was obtained with Ethics committee approval and informed consent obtained from BioIVT (Hicksville, NY) normal healthy adults (n = 6), adults with =1 sexual partner (n = 30), pediatric donors (age 1–5 days; n = 10), HPV+ serum from cervical cancer patients at CIN2/3 staging (Proteogenex Inglewood, CA; n = 3)...

• Lazarus, Hillard M.; Armitage, James O. and Gale, Robert Peter 2021-06-16 "Role of molecularly-cloned hematopoietic growth factors after acute high-dose radiation exposures" Journal of Radiological Protection

Given the favorable benefit-to-risk ratio of molecularly-cloned myeloid growth factors, their use soon after exposure to acute, high-dose whole-body ionizing radiations is reasonable.

• Lenc, Tomas; Merchant, Hugo; Keller, Peter E.; Honing, Henkjan; Varlet, Manuel and Nozaradan, Sylvie 2021-08-23 "Mapping between sound, brain and behaviour: four-level framework for understanding rhythm processing in humans and non-human primates" Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 376(1835):20200325
• Levy, Jonathan; Droz-Bartholet, François; Achour, Melyna; Facchinetti, Patricia; Parratte, Bernard and Giuliano, François 2021-09-01 "Parafacial neurons in the human brainstem express specific markers for neurons of the retrotrapezoid nucleus" The Journal of Comparative Neurology 529(13):3313-3320

The location of the RTN [retrotrapezoid nucleus] in human adults is provided. This should help to develop investigation tools combining anatomic high-resolution imaging and respiratory functional investigations to explore the pathogenic role of the RTN in congenital or acquired neurodegenerative diseases.

• Liu, Junhao; Yang, Zhou; Wu, Xiuhua; Huang, Zucheng; Huang, Zhiping; Chen, Xushi; Liu, Qi; Jiang, Hui and Zhu, Qingan 2021-02-06 "Comparison of the anatomical morphology of cervical vertebrae between humans and macaques: related to a spinal cord injury model" Experimental Animals 70(1):108-118
• Lopez-Persem, Alizée; Roumazeilles, Léa; Folloni, Davide; Marche, Kévin; Fouragnan, Elsa F.; Khalighinejad, Nima; Rushworth, Matthew F.S. and Sallet, Jérôme 2020-11-10 "Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates" Proceedings of the National Academy of Sciences of the United States of America 117(45):28452-28462

Using resting-state and reward-related functional MRI data from humans and from rhesus macaques...

• Lund, Merete; Pearson, Andrew C.; Sage, Megan A.G. and Duffy, Diane M. 2022-10-10 "Luteinizing Hormone Receptor Promotes Angiogenesis In Ovarian Endothelial Cells of Macaca fascicularis and Homo sapiens" Biology of Reproduction ioac189

Human ovarian microvascular endothelial cells (hOMECs) enriched from ovarian aspirates obtained from healthy oocyte donors...

• Lynn, Catherine and Curran, William 2010-10-12 "A comparison of monkey and human motion processing mechanisms" Vision Research 50(21):2137-2141
• Ma, Yuequn; Cao, Changying; Zhao, Mengwen; Liu, Xinhua; Cheng, Feng and Wang, Ju 2021-06-30 "Evolutionary Changes in Pathways and Networks of Genes Expressed in the Brains of Humans and Macaques" Journal of Molecular Neuroscience

Our results provide on a comprehensive view of the evolutionary pathways of the human CNS and can serve as a reference for the study of human brain development.

• Ma, Wenbo; Li, Min; Wu, Junru; Zhang, Zhihao; Jia, Fangfang; Zhang, Mingsha; Bergman, Hagai; Li, Xuemei; Ling, Zhipei and Xu, Xin 2022-07-27 "Multiple step saccades in simply reactive saccades could serve as a complementary biomarker for the early diagnosis of Parkinson's disease" Frontiers in Aging Neuroscience 14:912967
• Ma, Jinfa; Wu, Jane Y. and Zhu, Li 2022-08-10 "Detection of orthologous exons and isoforms using EGIO" Bioinformatics btac548

Unexpectedly, more human unique isoforms are detected than those conserved between humans and chimpanzees.

• Mac-Auliffe, Diego; Chatard, Benoit; Petton, Mathilde; Croizé, Anne-Claire; Sipp, Florian; Bontemps, Benjamin; Gannerie, Adrien; Bertrand, Olivier; Rheims, Sylvain; Kahane, Philippe and Lachaux, Jean-Philippe 2021-08-19 "The Dual-Task Cost Is Due to Neural Interferences Disrupting the Optimal Spatio-Temporal Dynamics of the Competing Tasks" Frontiers in Behavioral Neuroscience 15:640178

Intracranial EEG recordings (iEEG) were collected in 12 patients, candidates for epilepsy surgery...

• Makino, Chie; Watanabe, Akiko; Kato, Manabu; Shiozawa, Hideyuki; Takakusa, Hideo; Nakai, Daisuke; Honda, Tomoyo and Watanabe, Nobuaki 2022-03-19 "Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by ¹⁴C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies" Drug Metabolism and Pharmacokinetics 45:100459

In the present study, in vivo metabolic profiling in humans and monkeys after the oral administration of two ¹⁴C-labeled compounds was performed to investigate species differences of the cleavage pathways.

• Malassis, Raphaëlle; Dehaene, Stanislas and Fagot, Joël 2020-04-30 "Baboons (Papio papio) Process a Context-Free but Not a Context-Sensitive Grammar" Scientific Reports 10(1):7381

Eight university students participated in this study (five females, age range 21-28).

• Mansouri, Farshad Alizadeh; Buckley, Mark J. and Tanaka, Keiji 2022-02-01 "The neural substrate and underlying mechanisms of executive control fluctuations in primates" Progress in Neurobiology 209:102216

Human participants: 63 participants (university students) within the age range of 18-27 joined the study as volunteers.

• Mars, Rogier B.; Foxley, Sean; Verhagen, Lennart; Jbabdi, Saad; Sallet, Jérôme; Noonan, MaryAnn P.; Neubert, Franz-Xaver; Andersson, Jesper L.; Croxson, Paula L.; Dunbar, Robin I.M.; Khrapitchev, Alexandre A.; Sibson, Nicola R.; Miller, Karla L. and Rushworth, Matthew F.S. 2016-11-01 "The extreme capsule fiber complex in humans and macaque monkeys: a comparative diffusion MRI tractography study" Brain Structure & Function 221(8):4059-4071
• Mars, Rogier B.; Jbabdi, Saad; Sallet, Jérôme; O'Reilly, Jill X.; Croxson, Paula L.; Olivier, Etienne; Noonan, MaryAnn P.; Bergmann, Caroline; Mitchell, Anna S.; Baxter, Mark G.; Behrens, Timothy E.J.; Johansen-Berg, Heidi; Tomassini, Valentina; Miller, Karla L. and Rushworth, Matthew F.S. 2011-03-16 "Diffusion-weighted imaging tractography-based parcellation of the human parietal cortex and comparison with human and macaque resting-state functional connectivity" The Journal of Neuroscience 31(11):4087-4100
• Mars, Rogier B.; Sallet, Jérôme; Neubert, Franz-Xaver and Rushworth, Matthew F.S. 2013-06-25 "Connectivity profiles reveal the relationship between brain areas for social cognition in human and monkey temporoparietal cortex" Proceedings of the National Academy of Sciences of the United States of America 110(26):10806-10811

Human volunteers were used to validate some aspects of the work as well as to get data on brain function.

• Mau, M.; Südekum, K.-H.; Johann, A.; Sliwa, A. and Kaiser, T.M. 2010-06-01 "Indication of higher salivary α-amylase expression in hamadryas baboons and geladas compared to chimpanzees and humans" Journal of Medical Primatology 39(3):187-190
• Maylott, Sarah E.; Paukner, Annika; Ahn, Yeojin A. and Simpson, Elizabeth A. 2020-05-18 "Human and monkey infant attention to dynamic social and nonsocial stimuli" Developmental Psychobiology 62(6):841-857
• McFarland, Richard; Roebuck, Hettie; Yan, Yin; Majolo, Bonaventura; Li, Wu and Guo, Kun 2013-02-15 "Social interactions through the eyes of macaques and humans" PLoS One 8(2):e56437

Twenty six undergraduate students (10 males and 16 females…) with normal visual acuity participated in this study.

• McGuinty, Michaeline; Angel, Jonathan B.; Cooper, Curtis L.; Cowan, Juthaporn; MacPherson, Paul A.; Kumar, Ashok; Murthy, Sanjay; Sy, Richmond; Dennehy, Michelle; Tremblay, Nancy; Byrareddy, Siddappa N. and Cameron, D. William 2020-10-08 "Vedolizumab treatment across antiretroviral treatment interruption in chronic HIV infection: the HAVARTI protocol for a pilot dose-ranging clinical trial to assess safety, tolerance, immunological and virological activity" BMJ Open 10(10):e041359

The HIV-ART-vedolizumab-ATI (HAVARTI) trial is a single-arm, dose-ranging pilot trial in healthy HIV-positive adult volunteers receiving ART. Twelve consenting persons will be enrolled in sequential groups of 4 to each serial dosing vedolizumab regimen (300 mg, 150 mg, 75 mg). The primary outcomes are: (1) to assess the safety and tolerability of seven serial infusions of vedolizumab at each of three doses; (2) to identify the immunovirological measures, including pVL and T-cell kinetics, that characterise HIV/ART cases before, during, after vedolizumab treatment and ATI; and (3) to seek SVR of pVL after ATI. Secondary outcomes will include immune reconstitution and pVL suppression as well as immune reconstitution and long-term safety following re-initiation of ART in the absence of SVR.

• McKeon, E.J.; Beran, M.J. and Parrish, A.E. 2022-04-04 "Children (Homo sapiens), but not rhesus monkeys (Macaca mulatta), perceive the one-is-more illusion" Journal of Comparative Psychology
• Miladinović, Aleksandar; Quaia, Christian; Ajčević, Miloš; Diplotti, Laura; Cumming, Bruce G.; Pensiero, Stefano and Accardo, Agostino 2022-11-10 "Ocular-following responses in school-age children" PLoS One 17(11):e0277443

Ocular following eye movements...reliably reveal stereoanomalies, and, thus, might have clinical applications. ... We recorded ocular following responses...in 14 school-age children (6 to 13 years old, 9 males and 5 females), under recording conditions that closely mimic a clinical setting. The OFRs were acquired non-invasively by a custom developed high-resolution video-oculography system, described in this study. With the developed system we were able to non-invasively detect OFRs in all children in short recording sessions.

• Mizuta, Ken; Katou, Yoshitaka; Nakakita, Baku; Kishine, Aoi; Nosaka, Yoshiaki; Saito, Saki; Iwatani, Chizuru; Tsuchiya, Hideaki; Kawamoto, Ikuo; Nakaya, Masataka; Tsukiyama, Tomoyuki; Nagano, Masahiro; Kojima, Yoji; Nakamura, Tomonori; Yabuta, Yukihiro; Horie, Akihito; Mandai, Masaki; Ohta, Hiroshi and Saitou, Mitinori 2022-08-01 "Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys" The EMBO Journal e110815
• Moeller, Sebastian; Unakafov, Anton M.; Fischer, Julia; Gail, Alexander; Treue, Stefan and Kagan, Igor 2023-01-12 "Human and macaque pairs employ different coordination strategies in a transparent decision game" eLife e81641
• Mohl, Jeff T.; Pearson, John M. and Groh, Jennifer M. 2020-09-01 "Monkeys and humans implement causal inference to simultaneously localize auditory and visual stimuli" The Journal of Neuroscience 124(3):715-727

Here we present results from a novel behavioral task in which both monkeys (Macaca mulatta) and humans localized visual and auditory stimuli and reported their perceived sources through saccadic eye movements.

• Mortberg, Meredith A.; Zhao, Hien T.; Reidenbach, Andrew G.; Gentile, Juliana E.; Kuhn, Eric; O'Moore, Jill; Dooley, Patrick M.; Connors, Theresa R.; Mazur, Curt; Allen, Shona W.; Trombetta, Bianca A.; McManus, Alison J.; Moore, Matthew R.; Liu, Jiewu; Cabin, Deborah E.; Kordasiewicz, Holly B.; Mathews, Joel; Arnold, Steven E.; Vallabh, Sonia M. and Minikel, Eric Vallabh 2022-02-08 "PrP concentration in the central nervous system: regional variability, genotypic effects, and pharmacodynamic impact" JCI Insight e156532
• Mutai, Hideki; Wasano, Koichiro; Momozawa, Yukihide; Kamatani, Yoichiro; Miya, Fuyuki; Masuda, Sawako; Morimoto, Noriko; Nara, Kiyomitsu; Takahashi, Satoe; Tsunoda, Tatsuhiko; Homma, Kazuaki; Kubo, Michiaki and Matsunaga, Tatsuo 2020-04-15 "Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans" PLoS Genetics 16(4):e1008643
• Naganawa, Mika; Li, Songye; Nabulsi, Nabeel B.; Henry, Shannan; Zheng, Ming-Qiang; Pracitto, Richard; Cai, Zhengxin; Gao, Hong; Kapinos, Michael; Labaree, David; Matuskey, David; Huang, Yiyun and Carson, Richard E. 2020-08-28 "First-in-human evaluation of ¹⁸F-SynVesT-1, a novel radioligand for PET imaging of synaptic vesicle protein 2A" Journal of Nuclear Medicine

Eight healthy volunteers participated in a baseline study of 18F-SynVesT-1.

• Natu, Vaidehi S.; Arcaro, Michael J.; Barnett, Michael A.; Gomez, Jesse; Livingstone, Margaret; Grill-Spector, Kalanit and Weiner, Kevin S. 2021-01-01 "Sulcal Depth in the Medial Ventral Temporal Cortex Predicts the Location of a Place-Selective Region in Macaques, Children, and Adults" Cerebral Cortex (New York, N.Y. : 1991) 31(1):48-61

Twenty-six children (ages 5–12 years, 17 females) and 28 adults (ages 22–28 years, 14 females) participated in our study. ... MRI data were collected using a 3 T GE scanner in the Center for Cognitive and Neurobiological Imaging at Stanford University.

• Norcia, Anthony M.; Yakovleva, Alexandra; Hung, Bethany and Goldberg, Jeffrey L. 2020-09-01 "Dynamics of Contrast Decrement and Increment Responses in Human Visual Cortex" Translational Vision Science & Technology 9(10):6

The goal of the present experiments was to determine whether electrophysiologic response properties of the ON and OFF visual pathways observed in animal experimental models can be observed in humans.

...two key properties of ON versus OFF pathways found in single-unit recordings are recapitulated at the population level of activity that can be observed with scalp electrodes, allowing differential assessment of ON and OFF pathway activity in human.

• Nunez, Valerie; Gordon, James and Shapley, Robert 2022-04-12 "Signals from Single-Opponent cortical cells in the human cVEP" The Journal of Neuroscience JN-RM-0276-22

We used the chromatic visual evoked potential, the cVEP, to study responses in human visual cortex evoked by equiluminant color stimuli for six male and 11 female observers.

• Ong, Voon; Wills, Sarah; Watson, Deborah; Sandison, Taylor and Flanagan, Shawn 2021-10-18 "Metabolism, Excretion, and Mass Balance of [¹⁴C]-Rezafungin in Animals and Humans" Antimicrobial Agents and Chemotherapy AAC0139021

Studies using [¹⁴C]-radiolabeled rezafungin were conducted in rats, monkeys, and humans to characterize the mass balance, excretion, and pharmacokinetics of [¹⁴C]-rezafungin and to evaluate relative amounts of rezafungin metabolites compared with parent drug.

• Orczyk, John; Schroeder, Charles E.; Abeles, Ilana Y.; Gomez-Ramirez, Manuel; Butler, Pamela D. and Kajikawa, Yoshinao 2021-04-16 "Comparison of Scalp ERP to Faces in Macaques and Humans" Frontiers in Systems Neuroscience 15:667611
• Pan, Li; Ping, An; Schriver, Kenneth E.; Roe, Anna Wang; Zhu, Junming and Xu, Kedi 2023-01-30 "Infrared neural stimulation in human cerebral cortex" Brain Stimulation

Modulation of brain circuits by electrical stimulation has led to exciting and powerful therapies for diseases such as Parkinson's. ... Infrared Neural Stimulation (INS) is an emerging stimulation technology that stimulates neural tissue via delivery of tiny heat pulses. In nonhuman primates, this optical method provides focal intensity-dependent stimulation of the brain without tissue damage. However, whether INS application to the human central nervous system (CNS) is similarly effective is unknown. ... Our results suggest that INS is a promising tool for stimulation of functionally selective mesoscale circuits in the human brain, and may lead to advances in the future of precision medicine.

• Panchuelo, Rosa M. Sanchez; Eldeghaidy, Sally; Marshall, Andrew; McGlone, Francis; Francis, Susan T. and Favorov, Oleg 2020-11-01 "A nociresponsive specific area of human somatosensory cortex within BA3a: BA3c?" NeuroImage 221:117187

...we used high spatial resolution 7T fMRI to study the response to thermonoxious skin stimulation. We observed the predicted response of BA3a in the depth of the central sulcus in five human volunteers. ... Ablation of this region has been shown to reduce pain sensibility and might offer an effective means of ameliorating some pathological pain conditions.

• Parrish, Audrey and Beran, Michael J. 2021-03-16 "Children and monkeys overestimate the size of high-contrast stimuli" Attention, Perception & Psychophysics

Specifically, black letters on a white background (high contrast between figure and ground) are judged to be taller than gray letters and gray pseudoletters on a white background (low contrast between figure and ground) for adult humans. In the current study, we assessed whether this effect would extend to nonverbal stimuli (shapes) such that high-contrast shapes would lead to greater size estimates relative to low-contrast shapes for human children and rhesus monkeys in a two-choice discrimination task.

• Patoori, Sruti; Barnada, Samantha M.; Large, Christopher; Murray, John I. and Trizzino, Marco 2022-09-02 "Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors" Development dev.200413
• Pereiro, Xandra; Ruzafa, Noelia; Urcola, J. Haritz; Sharma, Sansar C. and Vecino, Elena 2020-12-07 "Differential Distribution of RBPMS in Pig, Rat, and Human Retina after Damage" International Journal of Molecular Sciences 21(23):9330

Donor human eyes (n = 3) were obtained within 24 h postmortem and all donated material was free of any known retinal pathology and contained no obvious ocular trauma or undiagnosed retinal injury at the time of tissue isolation.

• Phamnguyen, Thienan John; Wijayath, Manori; Bleasel, Andrew; Rahman, Zebunnessa; Bartley, Melissa; Dexter, Mark and Wong, Chong 2022-04-01 "Localisation and stimulation of the parietal eye field" Epileptic Disorders 24(2):404-410
• Pilz, Karin S.; Äijälä, Juho M. and Manassi, Mauro 2020-12-02 "Selective age-related changes in orientation perception" Journal of Vision 20(13):13
• Poirier, Donald; Nyachieo, Atunga; Romano, Andrea; Roy, Jenny; Maltais, René; Chai, Daniel; Delvoux, Bert; Tomassetti, Carla and Vanhie, Arne 2022-06-09 "An irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 inhibits estradiol synthesis in human endometriosis lesions and induces regression of the non-human primate endometriosis" The Journal of Steroid Biochemistry and Molecular Biology 106136
• Postans, M.; Parker, G.D.; Lundell, H.; Ptito, M.; Hamandi, K.; Gray, W.P.; Aggleton, J.P.; Dyrby, T.B.; Jones, D.K. and Winter, M. 2020-03-14 "Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory" Cerebral Cortex (New York, N.Y. : 1991) 30(3):1001-1015

The dorsal hippocampal commissure (DHC) is a white matter tract that provides interhemispheric connections between temporal lobe brain regions. Despite the importance of these regions for learning and memory, there is scant evidence of a role for the DHC in successful memory performance. We used diffusion-weighted magnetic resonance imaging (DW-MRI) and white matter tractography to reconstruct the DHC in both humans (in vivo) and nonhuman primates (ex vivo). ... These findings highlight a potential role for the DHC in recognition memory, and our tract reconstruction approach has the potential to generate further novel insights into the role of this previously understudied white matter tract in both health and disease.

• Priesemann, Viola; Wibral, Michael; Valderrama, Mario; Pröpper, Robert; Le Van Quyen, Michel; Geisel, Theo; Triesch, Jochen; Nikolic, Danko and Munk, Matthias H.J. 2014-06-24 "Spike avalanches in vivo suggest a driven, slightly subcritical brain state" Frontiers in Systems Neuroscience 8:108
• Priest, R.C.; Spaull, J.; Buckton, J.; Grimley, R.L.; Sims, M.; Binks, M. and Malhotra, R. 2009-03-01 "Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation" Clinical and Experimental Immunology 155(3):514-522

Similar tests were done on human tissue from volunteers.

• Rafal, Robert D.; Koller, Kristin; Bultitude, Janet H.; Mullins, Paul; Ward, Robert; Mitchell, Anna S. and Bell, Andrew H. 2015-09-01 "Connectivity between the superior colliculus and the amygdala in humans and macaque monkeys: virtual dissection with probabilistic DTI tractography" Journal of Neurophysiology 114(3):1947-1962
• Rajalingham, Rishi; Piccato, Aída and Jazayeri, Mehrdad 2022-10-04 "Recurrent neural networks with explicit representation of dynamic latent variables can mimic behavioral patterns in a physical inference task" Nature Communications 13(1):5865

Two adult monkeys (Macaca mulatta; female), and twelve human participants (18-65 years, gender not queried) participated in the experiments.

• Ramirez, Ana L.; Thompson, Lowell W.; Rosenberg, Ari and Baker, Curtis L. 2022-11-09 "Behavioral signatures of Y-like neuronal responses in human vision" Scientific Reports 12(1):19116
• Rasooly, Reuven; Do, Paula; He, Xiaohua and Hernlem, Bradley 2021-04-23 "Human Leukemia T-Cell Lines as Alternatives to Animal Use for Detecting Biologically Active Staphylococcal Enterotoxin Type B" Toxins 13(5):300

Staphylococcal enterotoxin type B (SEB) is associated with food poisoning. Current methods for the detection of biologically active SEB rely upon its ability to cause emesis when administered to live kittens or monkeys. This technique suffers from poor reproducibility and low sensitivity and is ethically disfavored over concerns for the welfare of laboratory animals. The data presented here show the first successful implementation of an alternative method to live animal testing that utilizes SEB super-antigenic activity to induce cytokine production for specific novel cell-based assays for quantifiable detection of active SEB.

• Raut, Ryan V.; Snyder, Abraham Z.; Mitra, Anish; Yellin, Dov; Fujii, Naotaka; Malach, Rafael and Raichle, Marcus E. 2021-07-21 "Global waves synchronize the brain's functional systems with fluctuating arousal" Science Advances 7(30):eabf2709
• Reeders, Puck C.; Núñez, M. Vanessa Rivera; Vertes, Robert P.; Mattfeld, Aaron T. and Allen, Timothy A. 2023-01-04 "Identifying the midline thalamus in humans in vivo" Brain Structure & Function

This anatomical connectivity-based identification of the midline thalamus offers the opportunity for necessary investigation of this region in vivo in the human brain and how it relates to cognitive functions in humans, and to psychiatric and neurological disorders.

• Ren, Jianxun; Xu, Ting; Wang, Danhong; Li, Meiling; Lin, Yuanxiang; Schoeppe, Franziska; Ramirez, Julian S.B.; Han, Ying; Luan, Guoming; Li, Luming; Liu, Hesheng and Ahveninen, Jyrki 2020-12-22 "Individual Variability in Functional Organization of the Human and Monkey Auditory Cortex" Cerebral Cortex (New York, N.Y. : 1991) bhaa366

...we examined the variability of ACs [auditory cortex] using intrinsic functional connectivity patterns in humans and macaques.

• Renner, Elizabeth; Kean, Donna; Atkinson, Mark and Caldwell, Christine A. 2021-01-13 "The use of individual, social, and animated cue information by capuchin monkeys and children in a touchscreen task" Scientific Reports 11(1):1043
• Richard, Nathalie; Desmurget, Michel; Teillac, Achille; Beuriat, Pierre-Aurélien; Bardi, Lara; Coudé, Gino; Szathmari, Alexandru; Mottolese, Carmine; Sirigu, Angela and Hiba, Bassem 2021-07-15 "Anatomical bases of fast parietal grasp control in humans: A diffusion-MRI tractography study" NeuroImage 235:118002

To date, projections from DPPC to M1 grasp zone have been identified in monkeys and have been postulated to exist in humans based on clinical and transcranial magnetic studies. This work uses diffusion-MRI tractography in two samples of right- (n = 50) and left-handed (n = 25) subjects randomly selected from the Human Connectome Project. ... Together, these results support the existence of a direct sensory-parietal-motor loop suited for fast manual control and more generally, for any task requiring rapid integration of distal sensorimotor signals.

• Rocchi, Francesca; Oya, Hiroyuki; Balezeau, Fabien; Billig, Alexander J.; Kocsis, Zsuzsanna; Jenison, Rick L.; Nourski, Kirill V.; Kovach, Christopher K.; Steinschneider, Mitchell; Kikuchi, Yukiko; Rhone, Ariane E.; Dlouhy, Brian J.; Kawasaki, Hiroto; Adolphs, Ralph; Greenlee, Jeremy D.W.; Griffiths, Timothy D.; Howard, Matthew A.; and Petkov, Christopher I. 2021-03-03 "Common fronto-temporal effective connectivity in humans and monkeys" Neuron 109(5):852-868.e8

We harnessed functional imaging to visualize the effects of direct electrical brain stimulation in macaque monkeys and human neurosurgery patients.

• Rogers Flattery, Christina N.; Coppeto, Daniel J.; Inoue, Kiyoshi; Rilling, James K.; Preuss, Todd M. and Young, Larry J. 2021-09-05 "Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species" Brain Structure & Function
• Roig, A.; Meunier, H.; Poulingue, E.; Marty, A.; Thouvarecq, R. and Rivière, J. 2022-04-07 "Is economic risk proneness in young children (Homo sapiens) driven by exploratory behavior? A comparison with capuchin monkeys (Sapajus apella)" Journal of Comparative Psychology
• Rokicki, Jaroslav; Kaufmann, Tobias; de Lange, Ann-Marie G.; van der Meer, Dennis; Bahrami, Shahram; Sartorius, Alina M.; Haukvik, Unn K.; Steen, Nils Eiel; Schwarz, Emanuel; Stein, Dan J.; Nærland, Terje; Andreassen, Ole A.; Westlye, Lars T. and Quintana, Daniel S. 2022-03-28 "Oxytocin receptor expression patterns in the human brain across development" Neuropsychopharmacology

We also show that a network of genes with strong spatiotemporal couplings with OXTR is enriched in several psychiatric illness and body composition phenotypes. Taken together, these results demonstrate that oxytocin signaling plays an important role in a diverse set of psychological and somatic processes across the lifespan.

• Rosenkrantz, Jimi L.; Gaffney, Jessica E.; Roberts, Victoria H.J.; Carbone, Lucia and Chavez, Shawn L. 2021-06-21 "Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation" BMC Biology 19(1):127

Here, we performed a cross-species transcriptomic comparison of human and rhesus placenta and determined that while the majority of human placental marker genes (HPGs) were similarly expressed, 952 differentially expressed genes (DEGs) were identified between the two species. ... Overall, our findings help elucidate the molecular translatability between human and rhesus placenta and reveal notable expression differences in several HPGs and genes implicated in pregnancy complications that should be considered when using the rhesus animal model to study normal and pathological human placentation.

• Roth, Zvi N.; Ryoo, Minyoung and Merriam, Elisha P. 2020-11-06 "Task-related activity in human visual cortex" PLoS Biology 18(11):e3000921

...we used functional MRI (fMRI) in human participants to study the link between arousal and endogenous responses in visual cortex.

• Ruebel, Meghan L.; Zambelli, Filippo; Schall, Peter Z.; Barragan, Montserrat; VandeVoort, Catherine A.; Vassena, Rita and Latham, Keith E. 2021-02-08 "Shared aspects of mRNA expression associated with oocyte maturation failure in humans and rhesus monkeys indicating compromised oocyte quality" Physiological Genomics
• Sablé-Meyer, Mathias; Fagot, Joël; Caparos, Serge; van Kerkoerle, Timo; Amalric, Marie and Dehaene, Stanislas 2021-04-20 "Sensitivity to geometric shape regularity in humans and baboons: A putative signature of human singularity" Proceedings of the National Academy of Sciences of the United States of America 118(16):e2023123118
• Saldana, Carmen; Claidière, Nicolas; Fagot, Joël and Smith, Kenny 2022-07-30 "Probability matching is not the default decision making strategy in human and non-human primates" Scientific Reports 12(1):13092

In this paper we report a set of four preregistered experiments testing adult humans and Guinea baboons on matched probability learning tasks, manipulating task complexity (binary or ternary prediction tasks) and reinforcement procedures (with and without corrective feedback). ...unlike other primates, adult humans probability match when the cost of pattern search is low.

• Santos-Mayo A, Moratti S, de Echegaray J, Susi G 2021-08-19 "A Model of the Early Visual System Based on Parallel Spike-Sequence Detection, Showing Orientation Selectivity" Biology 10(8):801
• Sato, Sho; Matsumiya, Kota; Tohyama, Kimio and Kosugi, Yohei 2021-06-03 "Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios" The AAPS Journal 23(4):81

The overall predictivity of the RAF [relative activity factors] approach is consistent with that of the relative expression factor (REF) approach. As the established model can predict K_p,uu,brain and K_p,uu,CSF using only in vitro and physicochemical data, this model would help avoid ethical issues related to animal use and improve CNS drug discovery workflow.

• Saul, Louise; Josephs, Debra H.; Cutler, Keith; Bradwell, Andrew; Karagiannis, Panagiotis; Selkirk, Chris; Gould, Hannah J.; Jones, Paul; Spicer, James F. and Karagiannis, Sophia N. 2014-03-01 "Comparative reactivity of human IgE to cynomolgus monkey and human effector cells and effects on IgE effector cell potency" mAbs 6(2):509-522

These data suggest that human IgE binds with different characteristics to human and cynomolgus monkey IgE effector cells. This is likely to affect the potency of IgE effector functions in these two species, and so has relevance for the selection of biologically-relevant model systems when designing pre-clinical toxicology and functional studies.

• Schach, Sonja; Lindner, Axel and Braun, Daniel Alexander 2022-10-13 "Bounded rational decision-making models suggest capacity-limited concurrent motor planning in human posterior parietal and frontal cortex" PLoS Computational Biology 18(10):e1010585

Here we study concurrent prospective motor planning in humans by recording functional magnetic resonance imaging (fMRI) during a delayed response task engaging movement sequences towards multiple potential targets.

• Schmitt, Constanze; Schwenk, Jakob C.B.; Schütz, Adrian; Churan, Jan; Kaminiarz, André and Bremmer, Frank 2021-07-02 "Preattentive processing of visually guided self-motion in humans and monkeys" Progress in Neurobiology 205:102117
• Schneider, Daniela; Bier, Dirk; Holschbach, Marcus; Bauer, Andreas and Neumaier, Bernd 2021-03-18 "Species Differences in Microsomal Metabolism of Xanthine-Derived A1 Adenosine Receptor Ligands" Pharmaceuticals (Basel, Switzerland) 14(3):277

The results revealed significant species differences regarding qualitative and quantitative aspects of microsomal metabolism. None of the tested animal species fully matched human microsomal metabolism of the three A1AR ligands. ... Surprisingly, rhesus macaques appear unsuitable due to large differences in metabolic activity towards the test compounds.

• Schöffski, P.; Concin, N.; Suarez, C.; Subbiah, V.; Ando, Y.; Ruan, S.; Wagner, J.P.; Mansfield, K.; Zhu, X.; Origuchi, S.; DiDominick, S.; Bialucha, C.; Faris, J.E. and Tran, B. 2021-08-19 "A Phase 1 Study of a CDH6-Targeting Antibody-Drug Conjugate in Patients with Advanced Solid Tumors with Evaluation of Inflammatory and Neurological Adverse Events" Oncology Research and Treatment 44:547-556

This first-in-human study (NCT02947152) evaluated the safety, tolerability, pharmacokinetics, and preliminary efficacy of HKT288, a first-in-class CDH6-targeting antibody-drug conjugate (ADC).

• Sharma, Vishakha; Creegan, Matthew; Tokarev, Andrey; Hsu, Denise; Slike, Bonnie M.; Sacdalan, Carlo; Chan, Phillip; Spudich, Serena; Ananworanich, Jintanat; Eller, Michael A.; Krebs, Shelly J.; Vasan, Sandhya; Bolton, Diane L.; the RV254/SEARCH010 and RV304/SEARCH013 Study Teams 2021-12-07 "Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection" PLoS Pathogens 17(12):e1010105
• Simone, Luciano; Viganò, Luca; Fornia, Luca; Howells, Henrietta; Leonetti, Antonella; Puglisi, Guglielmo; Bellacicca, Andrea; Bello, Lorenzo and Cerri, Gabriella 2021-04-07 "Distinct functional and structural connectivity of the human hand-knob supported by intraoperative findings" The Journal of Neuroscience 41(19): 4223-4233

The functional definition of the two hand-knob sectors, within a large cohort of patients, show they potentially play different roles in motor control suggesting that the human hand-knob is an anatomo-functional heterogeneous region organized along a motor-cognitive gradient.

• Smith, J.D.; Church, B.A.; Jackson, B.N.; Adamczyk, M.N.; Shaw, C.N. and Beran, M.J. 2021-01-14 "Launch! Self-agency as a discriminative cue for humans (Homo sapiens) and monkeys (Macaca Mulatta)" Journal of Experimental Psychology. General 150(9): 1901-1917

Humans and rhesus macaques learned event categories differentiated by whether the participant's volitional response controlled a screen launch.

• Solomon, Selina S.; Tang, Huizhen; Sussman, Elyse and Kohn, Adam 2021-03-04 "Limited Evidence for Sensory Prediction Error Responses in Visual Cortex of Macaques and Humans" Cerebral Cortex (New York, N.Y. : 1991) bhab014
• Souder, Dylan C.; Dreischmeier, Isabelle A.; Smith, Alex B.; Wright, Samantha; Martin, Stephen A.; Sagar, Md Abdul Kader; Eliceiri, Kevin W.; Salamat, Shahriar M.; Bendlin, Barbara B.; Colman, Ricki J.; Beasley, T. Mark and Anderson, Rozalyn M. 2021-05-05 "Rhesus monkeys as a translational model for late-onset Alzheimer's disease" Aging Cell e13374
• Speed, Bill; Bu, Hai-Zhi; Pool, William F.; Peng, Geoffrey W.; Wu, Ellen Y.; Patyna, Shem; Bello, Carlo and Kang, Ping 2012-03-01 "Pharmacokinetics, distribution, and metabolism of [¹⁴C]sunitinib in rats, monkeys, and humans" Drug Metabolism and Disposition 40(3):539-555
• Sponheim, Caleb Scheffer; Papadourakis, Vasileios; Collinger, Jennifer; Downey, John; Weiss, Jeffrey M.; Pentousi, Lida; Elliott, Kaisa and Hatsopoulos, Nicholas 2021-11-30 "Longevity and reliability of chronic unit recordings using the Utah, intracortical multi-electrode arrays" Journal of Neural Engineering

We collected and analyzed over 6000 recorded datasets from various cortical areas spanning almost 9 years of experiments, totaling 17 rhesus macaques (Macaca Mulatta) and 2 human subjects, and 55 separate microelectrode Utah arrays. ... Using implants in primary motor, premotor, prefrontal, and somatosensory cortices, we found that the average lifespan of available recordings from UEAs was 622 days, although we provide several examples of these UEAs lasting over 1000 days and one up to 9 years; human implants were also shown to last longer than non-human primate implants.

• Sugiyama, Taisei; Nakae, Keita and Izawa, Jun 2022-11-02 "Transcranial magnetic stimulation on the dorsal premotor cortex facilitates human visuomotor adaptation" NeuroReport 33(16):723-727

Since noninvasive neuromodulation is a promising tool for research and clinical practice, the present study demonstrates that PMd [dorsal premotor cortex] is a feasible target region of neuromodulation to understand human motor adaptation and improve motor rehabilitation.

• Szczupak, Diego; Yen, Cecil C.; Liu, Cirong; Tian, Xiaoguang; Lent, Roberto; Tovar-Moll, Fernanda and Silva, Afonso C. 2020-12-21 "Dynamic Interhemispheric Desynchronization in Marmosets and Humans With Disorders of the Corpus Callosum" Frontiers in Neural Circuits 14:612595

We also performed rsfMRI in 10 CCD human subjects (six hypoplasic and four agenesic).

• Szczupak, Diego; Iack, Pamela Meneses; Rayêe, Danielle; Liu, Cirong; Lent, Roberto; Tovar-Moll, Fernanda and Silva, Afonso C. 2022-09-30 "The relevance of heterotopic callosal fibers to interhemispheric connectivity of the mammalian brain" Cerebral Cortex bhac377
• Takahashi, Kayo; Hosoya, Takamitsu; Onoe, Kayo; Mori, Tomoko; Tazawa, Shusaku; Mawatari, Aya; Wada, Yasuhiro; Watanabe, Yumiko; Doi, Hisashi and Watanabe, Yasuyoshi 2021-12-08 "PET imaging of brain aromatase in humans and rhesus monkeys by ¹¹C-labeled cetrozole analogs" Scientific Reports 11(1):23623

The most promising analog in the monkey study, iso-cetrozole, was evaluated in the human PET study.

• Tapmeier TT, Rahmioglu N, Lin J, et al 2021-08-25 "Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis" Science Translational Medicine 13:eabd6469

We leveraged genetic analyses in two species with spontaneous endometriosis, humans and the rhesus macaque, to uncover treatment targets.

• Taubert, Nick; Stettler, Michael; Siebert, Ramona; Spadacenta, Silvia; Sting, Louisa; Dicke, Peter; Thier, Peter and Giese, Martin A. 2021-06-11 "Shape-invariant encoding of dynamic primate facial expressions in human perception" eLife 10:e61197
• Thomas, John; Sharma, Dixit; Mohanta, Sounak and Jain, Neeraj 2021-03-01 "Resting-State functional networks of different topographic representations in the somatosensory cortex of macaque monkeys and humans" NeuroImage 228:117694

Data from human subjects were acquired in the same 3-T MRI scanner but using an 8 channel SENSE head coil.

• Toda, Akiko; Shimizu, Makiko; Uehara, Shotaro; Sasaki, Tatsuro; Miura, Tomonori; Mogi, Masayuki; Utoh, Masahiro; Suemizu, Hiroshi and Yamazaki, Hiroshi 2021-03-01 "Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling" Xenobiotica; The Fate of Foreign Compounds in Biological Systems 51(3):316-323
• Toker, Daniel; Pappas, Ioannis; Lendner, Janna D.; Frohlich, Joel; Mateos, Diego M.; Muthukumaraswamy, Suresh; Carhart-Harris, Robin; Paff, Michelle; Vespa, Paul M.; Monti, Martin M.; Sommer, Friedrich T.; Knight, Robert T. and D'Esposito, Mark 2022-02-15 "Consciousness is supported by near-critical slow cortical electrodynamics" Proceedings of the National Academy of Sciences of the United States of America 119(7):e2024455119

We therefore applied the modified 0-1 chaos test to low-frequency activity extracted from surface electrocorticography (ECoG) recordings of the cortical electrodynamics of two macaques and five human epilepsy patients during normal waking states, of two macaques and three human epilepsy patients under GABAergic (propofol or propofol and sevoflurane) anesthesia, and of two human epilepsy patients experiencing generalized seizures; we further applied this test to magnetoencephalography (MEG) recordings of the cortical electrodynamics of a third human epilepsy patient experiencing a generalized seizure. We also applied the 0-1 chaos test to the low-frequency component of MEG recordings of the cortical electrodynamics of 16 human subjects under the influence of either a saline placebo or LSD...

• Völter, Christoph J.; Reindl, Eva; Felsche, Elisa; Civelek, Zeynep; Whalen, Andrew; Lugosi, Zsuzsa; Duncan, Lisa; Herrmann, Esther; Call, Josep and Seed, Amanda M. 2022-04-19 "The structure of executive functions in preschool children and chimpanzees" Scientific Reports 12(1):6456
• Vos de Wael, Reinder; Royer, Jessica; Tavakol, Shahin; Wang, Yezhou; Paquola, Casey; Benkarim, Oualid; Eichert, Nicole; Larivière, Sara; Xu, Ting; Misic, Bratislav; Smallwood, Jonathan; Valk, Sofie L. and Bernhardt, Boris C. 2021-06-19 "Structural Connectivity Gradients of the Temporal Lobe Serve as Multiscale Axes of Brain Organization and Cortical Evolution" Cerebral Cortex 31(11): 5151-5164
• Wallace, Mark N.; Zobay, Oliver; Hardman, Eden; Thompson, Zoe; Dobbs, Phillipa; Chakrabarti, Lisa and Palmer, Alan R. 2022-11-09 "The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity" Frontiers in Neuroanatomy 16:1034264
• Wan, Bin; Bayrak, Seyma; Xu, Ting Ting; Schaare, H. Lina; Bethlehem, Richard A.I.; Bernhardt, Boris C. and Valk, Sofie Louise 2022-07-29 "Heritability and cross-species comparisons of human cortical functional organization asymmetry" eLife 11:e77215

However, both language and frontoparietal networks showed a qualitatively larger asymmetry in humans relative to macaques.

• Wang, Jiaojiang; Yang, Yang; Zhao, Xudong; Zuod, Zhentao and Tan, Li-Hai 2020-11-15 "Evolutional and developmental anatomical architecture of the left inferior frontal gyrus" NeuroImage 222:117268
• Wang, Jiarui; Tao, Annabelle; Anderson, William S.; Madsen, Joseph R. and Kreiman, Gabriel 2021-08-24 "Mesoscopic physiological interactions in the human brain reveal small-world properties" Cell Reports 36(8):109585

Recorded continuous intracranial field potentials for 5 days in 48 human subjects

• Wang, Liping; Uhrig, Lynn; Jarraya, Bechir and Dehaene, Stanislas 2015-08-03 "Representation of Numerical and Sequential Patterns in Macaque and Human Brains" Current Biology 25(15):1966-1974

Using fMRI in untrained macaques and humans, we investigated the brain areas involved in representing two abstract properties of a series of tones: total number of items and tone-repetition pattern.

• Warrington, Shaun; Bryant, Katherine L.; Khrapitchev, Alexandr A.; Sallet, Jerome; Charquero-Ballester, Marina; Douaud, Gwenaëlle; Jbabdi, Saad; Mars, Rogier B. and Sotiropoulos, Stamatios N. 2020-08-15 "XTRACT - Standardised protocols for automated tractography in the human and macaque brain" NeuroImage 217:116923

We present a new software package with a library of standardised tractography protocols devised for the robust automated extraction of white matter tracts both in the human and the macaque brain.

• Warrington, Shaun; Thompson, Elinor; Bastiani, Matteo; Dubois, Jessica; Baxter, Luke; Slater, Rebeccah; Jbabdi, Saad; Mars, Rogier B. and Sotiropoulos, Stamatios N. 2022-10-21 "Concurrent mapping of brain ontogeny and phylogeny within a common space: Standardized tractography and applications" Science Advances 8(42):eabq2022

Neonatal data
dMRI data were drawn from 438 neonates...acquired during natural sleep...
Adult data
We drew from the preprocessed, publicly released HCP dMRI data...

• Watson, Stuart K.; Burkart, Judith M.; Schapiro, Steven J.; Lambeth, Susan P.; Mueller, Jutta L. and Townsend, Simon W. 2020-10-21 "Nonadjacent dependency processing in monkeys, apes, and humans" Science Advances 6(43):eabb0725

Here, we examined nonadjacent dependency processing in common marmosets, chimpanzees, and humans using "artificial grammars": strings of arbitrary acoustic stimuli composed of adjacent (nonhumans) or nonadjacent (all species) dependencies.

• Wen, Haojie; Xu, Ting; Wang, Xiaoying; Yu, Xi and Bi, Yanchao 2022-09-01 "Brain intrinsic connection patterns underlying tool processing in human adults are present in neonates and not in macaques" NeuroImage 258:119339
• Wesselink, Daan B.; Sanders, Zeena-Britt; Edmondson, Laura R.; Dempsey-Jones, Harriet; Kieliba, Paulina; Kikkert, Sanne; Themistocleous, Andreas C.; Emir, Uzay; Diedrichsen, Jörn; Saal, Hannes P. and Makin, Tamar R. 2022-04-22 "Malleability of the cortical hand map following a finger nerve block" Science Advances 8(16):eabk2393

Our findings therefore open up previously unidentified opportunities for restorative applications and brain-computer interface control.

• Westerberg; Jacob A.; Schall, Michelle S.; Maier, Alexander; Woodman, Geoffrey F. and Schall, Jeffrey D. 2022-01-28 "Laminar microcircuitry of visual cortex producing attention-associated electric fields" eLife 11:e72139

Here we detail the laminar cortical circuitry underlying an attention-associated electric field measured over posterior regions of the brain in humans and monkeys.

• Wilson, Benjamin; Kikuchi, Yukiko; Sun, Li; Hunter, David; Dick, Frederic; Smith, Kenny; Thiele, Alexander; Griffiths, Timothy D.; Marslen-Wilson, William D. and Petkov, Christopher I. 2015-11-17 "Auditory sequence processing reveals evolutionarily conserved regions of frontal cortex in macaques and humans" Nature Communications 6:8901
• Wilson, Benjamin; Smith, Kenny and Petkov, Christopher I. 2015-03-01 "Mixed-complexity artificial grammar learning in humans and macaque monkeys: Evaluating learning strategies" The European Journal of Neuroscience 41(5):568-578

The stimuli in the Rhesus macaque and the human experiments were identical.

• Wu, Zhemeng; Kavanova, Martina; Hickman, Lydia; Lin, Fiona and Buckley, Mark J. 2020-06-15 "Similar time course of fast familiarity and slow recollection processes for recognition memory in humans and macaques" Learning & Memory (Cold Spring Harbor, N.Y.) 27(7):258-269
• Xia, Xiaoluan; Gao, Fei and Yuan, Zhen 2021-09-23 "Species and individual differences and connectional asymmetry of Broca's area in humans and macaques" NeuroImage 244:118583
• Yan, Chao-Chao; Zhang, Xin-Shang; Zhou, Liang; Yang, Qiao; Zhou, Min; Zhang, Lin-Wan; Xing, Jin-Chuan; Yan, Zhi-Feng; Price, Megan; Li, Jing; Yue, Bi-Song and Fan, Zhen-Xin 2020-09-18 "Effects of aging on gene expression in blood of captive Tibetan macaques (Macaca thibetana) and comparisons with expression in humans" Zoological Research 41(5):557-563
• Yan, Weixin; Xie, Lingpeng; Bi, Yanmeng; Zeng, Ting; Zhao, Di; Lai, Yuqi; Gao, Tingting; Sun, Xuegang; Shi, Yafei; Dong, Zhaoyang; Wen, Ge; Gao, Lei and Lv, Zhiping 2021-10-12 "Combined rs-fMRI study on brain functional imaging and mechanism of RAGE-DAMPs of depression: Evidence from MDD patients to chronic stress-induced depression models in cynomolgus monkeys and mice" Clinical and Translational Medicine 11(10):e541

...we investigated change of brain functional imaging and the inflammatory mechanism of damage-related molecular patterns (DAMPs)-receptor of advanced glycation protein end product (RAGE) in MDD [major depressive disorder] patients and depressive-like cynomolgus monkeys and mice models induced by chronic stress.

• Yan, Yuke; Sobinov, Anton R. and Bensmaia, Sliman J. 2022-06-01 "Prehension kinematics in humans and macaques" Journal of Neurophysiology 127(6):1669-1678

While the structure of the pre-shaping hand postures is similar in humans and macaques, human postures are more object-specific and human joints are less intercorrelated. Conversely, monkeys demonstrate more stereotypical pre-shaping behaviors that are common across all objects and more variability in their postures across repeated presentations of the same object.

• Yang, Yun; Zhang, Qian; Yang, Jing; Wang, Yun; Zhuang, Ke and Zhao, Changcheng 2022-08-29 "Possible Association of Nucleobindin-1 Protein with Depressive Disorder in Patients with HIV Infection" Brain Sciences 12(9):1151

Individuals who were newly HIV diagnosed were assessed on the Hospital Anxiety and Depression scale (HADS). Then SHIV-infected rhesus monkeys were used to investigate the possible involvement of the NUCB1 and the CNR1 protein in depression-like behavior. ... The prevalence rate of depression among PLWHA was 27.33% (41/150). The mechanism results showing elevated NUCB1 levels in cerebrospinal fluid from HIV-infected patients suffering from depression were confirmed compared to those of HIV-infected patients.

• Yu, Rosie Z.; Wang, Yanfeng; Norris, Dan A.; Kim, Tae-Won; Narayanan, Padma; Geary, Richard S.; Monia, Brett P. and Henry, Scott P. 2020-10-09 "Immunogenicity Assessment of Inotersen, a 2'-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety" Nucleic Acid Therapeutics 30(5):265-275

The IM [potential immunogenicity] of inotersen in humans was evaluated in a pivotal phase 2/3 clinical study in patients with hereditary TTR [hereditary transthyretin] amyloid polyneuropathy (hATTR-PN).

• Yue, Xiaomin; Robert, Sophia and Ungerleider, Leslie G. 2020-11-15 "Curvature processing in human visual cortical areas" NeuroImage 222:117295

15 subjects (11 female, age range 22–40 years) participated in the fMRI experiment, 12 of whom (8 female, age range 22–40 years) underwent retinotopic mapping.

• Yurt, Pinar; Calapai, Antonino; Mundry, Roger and Treue, Stefan 2022-12-20 "Assessing cognitive flexibility in humans and rhesus macaques with visual motion and neutral distractors" Frontiers in Psychology 13:1047292
• Zanini, A.; Patané, I.; Blini, E.; Salemme, R.; Koun, E.; Farnè, A. and Brozzoli, C. 2021-06-22 "Peripersonal and reaching space differ: Evidence from their spatial extent and multisensory facilitation pattern" Psychonomic Bulletin & Review

Peripersonal space (PPS) is a multisensory representation of the space near body parts facilitating interactions with the close environment. Studies on non-human and human primates agree in showing that PPS is a body part-centered representation that guides actions. Because of these characteristics, growing confusion surrounds peripersonal and arm-reaching space (ARS), that is the space one's arm can reach. Despite neuroanatomical evidence favoring their distinction, no study has contrasted directly their respective extent and behavioral features. Here, in five experiments (N = 140) we found that PPS differs from ARS, as evidenced both by participants' spatial and temporal performance and by its modeling. We mapped PPS and ARS using both their respective gold standard tasks and a novel multisensory facilitation paradigm.

• Zhang, He; Zhen, Yanfen; Yu, Shijing; Long, Tenghai; Zhang, Bingqian; Jiang, Xinjian; Li, Junru; Fang, Wen; Sigman, Mariano; Dehaene, Stanislas and Wang, Liping 2021-12-02 "Working memory for spatial sequences: Developmental and evolutionary factors in encoding ordinal and relational structures" The Journal of Neuroscience

Most importantly, only humans, regardless of age, spontaneously extracted the spatial relations between consecutive items and used a chunking strategy to compress sequences in working memory. Monkeys did not detect such relational structures, even after extensive training.

• Zhou, Xiaoxu; Jeong, Euy-Myoung; Liu, Hong; Kaseer, Bahaa; Liu, Man; Shrestha, Suvash; Imran, Hafiz; Kavanagh, Kylie; Jiang, Ning; Desimone, Lori-Ann; Feng, Feng; Shi, Guangbin; Jeong, Go Eun; Zhou, Anyu; Stockwell, Philip and Dudley, Samuel C. 2022-06-03 "Circulating S-Glutathionylated cMyBP-C as a Biomarker for Cardiac Diastolic Dysfunction" Journal of the American Heart Association e025295
• Zhu T, Lei M, Wang Z, et al 2021-10-28 "A Comparative Study of Systolic and Diastolic Mechanical Synchrony in Canine, Primate, and Healthy and Failing Human Hearts" Frontiers in Cardiovascular Medicine 8:750067
• Zimmermann, Eckart; Ghio, Marta; Pergola, Giulio; Koch, Benno; Schwarz, Michael and Bellebaum, Christian 2020-10-01 "Separate and overlapping functional roles for efference copies in the human thalamus" Neuropsychologia 147:107558

We studied patients with medial or lateral thalamic lesions (likely involving either the MD [medio-dorsal] or the ventrolateral (VL) nuclei). Patients performed a double-step task testing motor updating, a trans-saccadic localization task testing visual updating, and a localization task during fixation testing a general role of motor signals for visual space in the absence of eye movements.

• Zuo, Shuzhen; Wang, Lei; Shin, Jung Han; Cai, Yudian; Zhang, Boqiang; Lee, Sang Wan; Appiah, Kofi; Zhou, Yong-di and Kwok, Sze Chai 2020-04-20 "Behavioral evidence for memory replay of video episodes in the macaque" eLife 9:e54519

Humans also used.